LSE Center Publications

 Publications

  1. Qarawani A, Naaman E, Tzvi Elimelech RB, Harel M, Itzkovich C, Safuri S, Dahan N, Henkin J, Soudry S., (2024). “PEDF-derived peptide protects against Amyloid-β toxicity in vitro and prevents retinal dysfunction in rats.” Exp Eye Res. 2024 Mar 22:109861. doi: 10.1016/j.exer.2024.109861
  2. Hashimshony T, Levin L, Fröbius AC, Dahan N, Chalifa-Caspi V, Hamo R, Gabai-Almog O, Blais I, Assaraf YG, Lubzens E., (2024). “A transcriptomic examination of encased rotifer embryos reveals the developmental trajectory leading to long-term dormancy; are they “animal seeds”?.” BMC Genomics. 2024 Jan 27;25(1):119. doi: 10.1186/s12864-024-09961-1.
  3. Kaduri M, Sela M, Kagan S,  Poley M,  Abumanhal-Masarweh H,  Mora-Raimundo P, Ouro A, Dahan N, Shklover J, Shainsky-Roitman J, Buganim Y, Schroeder A., (2021)Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases. Sci Adv. 2021 Oct 8;7(41) doi:10.1126/sciadv.abj5435. Epub 2021 Oct 6.
  4. Korsensky L, Chorev D, Saleem H, Heller-Japheth R, Rabinovitz S, Haif S, Dahan N, Ziv T, Ron D, (2021). “Regulation of stability and inhibitory activity of the tumor suppressor SEF through casein-kinase 2-mediated phosphorylation.” Cell Signal. 2021 Jul 16:110085. DOI: 10.1016/j.cellsig.2021.110085
  5. Davidov T., Efraim Y., Dahan N., Baruch L., Machluf M., (2020). “Porcine arterial ECM hydrogel: Designing an in vitro angiogenesis model for long-term high-throughput research”. FASEB. DOI: 10.1096/fj.202000264.
  6. Eid Mutlak Y., Aweida D., Volodin A., Ayalon B., Dahan N., Parnis A., Cohen S., (2020). “A signaling hub of insulin receptor, dystrophin glycoprotein complex an plakoglobin regulates muscle size”. Nature Communications. DOI: 10.1038/s41467-020-14895-9.
  7. Korsensky L., Haif S., Heller R., Rabinovitz S., Haddad-Halloun J., Dahan N., Ron D., (2019). “The tumor suppressor Sef is a scaffold for the classical NF-κB/RELA:P50 signaling module”. Cellular Signalling. DOI: 10.1016/j.cellsig.2019.01.009
  8. Abumanhal-Masarweh H., Koren L., Zinger A., Yaari Z., Krinsky N., Kaneti G., Dahan N., Lupu-Haber Y., Suss-Toby E., Weiss-Messer E., Schlesinger-Laufer M., Shainsky-Roitman J., Schroeder A., (2019). “Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin”. Journal of Controlled Release. DOI: 10.1016/j.jconrel.2019.01.004.
  9. Chu G., Vasilyev G., Vilensky R., Boaz M., Zhang R., Martin P., Dahan N., Deng S., Zussman E., (2018). “Controlled Assembly of Nanocellulose-Stabilized Emulsions with Periodic Liquid Crystal-in-Liquid Crystal Organization”. Langmuir. DOI: 10.1021/acs.langmuir.8b02163.
  10. Yaari Z., da Silva D., Zinger A., Goldman E., Kajal A., Tshuva R., Barak E., Dahan N., Hershkovitz D., Goldfeder M., Roitman J.S., Schroeder A., (2016). “Theranostic barcoded nanoparticles for personalized cancer medicine”. Nat Communications. DOI: 10.1038/ncomms13325.
  11. Kirzner S, Barak E, Lindell D. Variability in progeny production and virulence of cyanophages determined at the single-cell level. Environ Microbiol Rep. 2016 Oct;8(5):605-613. doi: 10.1111/1758-2229.12409. Epub 2016 May 30. PMID: 27084786.

Acknowledgments (last 5 years)

    • Renana F, Sabine B, Veronica O, George B, Ramu D, Isabelle Q, Michal A, Eleni P, Polina T, Roni N, Peter J, Dan Z,. “A divergent protein kinase A regulatory subunit essential for morphogenesis of the human pathogen Leishmania”. PLoS Pathog. 2024 Mar 29;20(3):e1012073. doi: 10.1371/journal.ppat.1012073.
    • Venezian J, Bar-Yosef H, Ben-Arie Zilberman H, Cohen N, Kleifeld O, Fernandez-Recio J, Glaser F, Shiber A. “Diverging co-translational protein complex assembly pathways are governed by interface energy distribution.” Nat Commun. 2024 Mar 25;15(1):2638. doi: 10.1038/s41467-024-46881-w.
    • Vaknin I, Willinger O, Mandl J, Heuberger H, Ben-Ami D, Zeng Y, Goldberg S, Orenstein Y, Amit R. “A universal system for boosting gene expression in eukaryotic cell-lines.” Nat Commun. 2024 Mar 16;15(1):2394. doi.org/10.1038/s41467-024-46573-5
    • Tiwari A, Haj N, Elgrably B, Berihu M, Laskov V, Barash S, Zigron S, Sason H, Shamay Y, Karni-Ashkenazi S, Holdengreber M, Saar G, Vandoorne K.”Cross-Modal Imaging Reveals Nanoparticle Uptake Dynamics in Hematopoietic Bone Marrow during Inflammation.”ACS Nano. 2024 Mar 5;18(9):7098-7113. doi: 10.1021/acsnano.3c11201. Epub 2024 Feb 11.
    • Hasan M, Panda D, Mann G, Brik A. “De novo Semi-synthetic Platform for Monitoring Protein degradation in Live Cells.” Chembiochem. 2023 Nov 30:e202300731. doi: 10.1002/cbic.202300731.
    • Maniv I, Sarji M, Bdarneh A, Feldman A, Ankawa R, Koren E, Magid-Gold I, Reis N, Soteriou D, Salomon-Zimri S, Lavy T, Kesselman E, Koifman N, Kurz T, Kleifeld O, Michaelson D, van Leeuwen FW, Verheijen BM, Fuchs Y, Glickman MH. “Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model.” Nat Commun. 2023 Sep 22;14(1):5922. doi: 10.1038/s41467-023-41545-7.
    • Ben-Oz BM, Machour FE, Nicola M, Argoetti A, Polyak G, Hanna R, Kleifeld O, Mandel-Gutfreund Y, Ayoub N. “A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response” Nat Commun. 2023 Nov 22;14(1):7628. doi: 10.1038/s41467-023-43495-6.
    • Sela M., Poley M., Mora-Raimundo P., Kagan S., Avital A., Kaduri M., Chen G., Adir O., Rozencweig A., Weiss Y., Sade O., Leichtmann-Bardoogo Y., Simchi L., Age-Mizrachi S., Bell B., Yeretz-Peretz Y., Zaid Or A., Choudhary A., Rosh I., Cordeiro D., Choen-Adiv S., Berdichevsky Y., Ode A., Shklover J., Shainsky-Roitman J., Schroeder J.E., Hershkovitz D., Hasson P., Ashkenazi A., Stern S., Laviv T., Ben-Zvi A., Avital A., Ashery U., Maoz B.M., Schroeder A.  “Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms of Parkinson’s Disease”. Advanced Materials.(2023). DOI:1002/adma.202304654.
    • Zlotver I., Sosnik A.  ” Glucosylated Hybrid TiO2/Polymer Nanomaterials for Actively Targeted Sonodynamic Therapy of Cancer”. Small (2023).. DOI: 10.1002/smll.202305475.
    • Sosnik A., Zlotver I., Peled E. “Galactomannan-graft-poly(methyl methacrylate) nanoparticles induce an anti-inflammatory phenotype in human macrophages”. Journal of Materials Chemistry B.(2023). DOI: 10.1039/D3TB01397A.
    • Roitman, S., Rozenberg, A., Lavy, T. et al. Isolation and infection cycle of a polinton-like virus virophage in an abundant marine alga. Nat Microbiol (2023). https://doi.org/10.1038/s41564-022-01305-7
    • Wyrobnik I, Steinberg M, Gelfand A, Rosenblum R, Eid Mutlak Y, Sulimani L, Procaccia S, Ofran Y, Novak-Kotzer H, Meiri D.eCollection 2023. Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression. Oncoimmunology. 2023 Jun 11;12(1):2219164. doi: 10.1080/2162402X.2023.2219164.
    • Vaknin, I., Amit, R., 2022. Molecular and experimental tools to design synthetic enhancers. Current Opinion in Biotechnology 76, 102728. https://doi.org/10.1016/j.copbio.2022.102728.
    • Granik N., Katz N., Willinger O., Goldberg S., Amit R. “Formation of synthetic RNA protein granules using engineered phage-coat-protein -RNA complexes”. Nature Communication (2022). DOI: 10.1038/s41467-022-34644-4
    • Chen G, Levin R, Landau S, Kaduri M, Adir O, Ianovici I, Krinsky N, Doppelt-Flikshtain O, Shklover J, Shainsky-Roitman J, Levenberg S, and Schroeder A. “Implanted synthetic cells trigger tissue angiogenesis through de novo production of recombinant growth factors” PNAS ,Sep 12, 2022, 119 (38) e2207525119.  https://doi.org/10.1073/pnas.2207525119
    • Sharma V.K., Stark M., Fridman N., Assaraf Y.G., Gross Z.  “Doubly Stimulated Corrole for Organelle-Selective Antitumor Cytotoxicity”. J Medicinal Chemistry(2022). DOI: 10.1021/acs.jmedchem.1c02085.
    • Koren E, Feldman A, Yusupova M , Kadosh A, Sedov E, Ankawa R, Yosefzon Y, Nasser W, Gerstberger S, Kimel L, Priselac N, Brown S, Sharma S, Gorenc T, Shalom-Feuerstein R, Steller H, Shemesh T, Fuchs Y. “Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis” Nat Commun, 2022 Aug 8;13(1):4628. doi: 10.1038/s41467-022-31629-1.
    • Halamish HM, Zlotver I, Sosnik A. Polymeric “Nanoparticles Surface-Complexed with Boric Acid Actively Target Solid Tumors Overexpressing Sialic Acid”  Journal of Colloid and Interface Science, 2022 Nov; https://doi.org/10.1016/j.jcis.2022.07.027 .
    • Shani-Zerbib L, Garion L, Maroudas-Sacks Y, Braun E, Keren K. “Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in Hydra Regeneration.” Genes (Basel). 2022 Feb 16;13(2):360. doi: 10.3390/genes13020360.
    • Arber Raviv S., Alyan M., Egorov E., Zano A., Yaskin Harush M., Pieters C., Korach-Rechtman H., Saadya A., Kaneti G., Nudelman I., Farkash S., Doppelt Flikshtain O., Mekies L.N., Koren L., Gal Y., Dor E., Shainsky J., Shklover J., Adir Y., Schroeder A. (2022). “Lung targeted liposomes for treating ARDS”. Journal of Controlled Release.
    • Mann G., Sadhu P., Brik A. (2022). “Multiplexed Delivery of Synthetic (Un)Conjugatable Ubiquitin and SUMO2 Enables Simultaneous Monitoring of their Localization and Function in Live Cells”. ChemBioChem. DOI: 10.1002/cbic.202200122.
    • Perelsman O, Asano S, Freifeld L. ” Expansion Microscopy of Larval Zebrafish Brains and Zebrafish Embryos.” Methods Mol Biol. 2022;2440:211-222. doi: 10.1007/978-1-0716-2051-9_13.
      PMID: 35218542.
    • Fridman Y, Strauss S, Horev G, Ackerman-Lavert M, Reiner-Benaim A, Lane B, Smith RS, Savaldi-Goldstein S. “The root meristem is shaped by brassinosteroid control of cell geometry.” Nat Plants. 2021 Nov;7(11):1475-1484. doi: 10.1038/s41477-021-01014-9. Epub 2021 Nov 15.PMID: 34782771
    • Davidov T., Efraim Y., Hayam R., Oieni J., Baruch L., Machluf M. (2021). “Extracellular Matrix Hydrogels Originated from Different Organs Mediate Tissue-Specific Properties and Function”. International Journal of Molecular Sciences. DOI: 10.3390/ijms222111624.
    • Peled E., Sosnik A. (2021). “Amphiphilic galactomannan nanoparticles trigger the alternative activation of murine macrophages”. Journal of Controlled Release. DOI: 10.1016/j.jconrel.2021.10.017.
    • Ackerman-Lavert M., Fridman Y., Matosevich R., Khandal H., Friedlander-Shani L., Vragovic K., Ben El R., Horev G., Tarkowska D., Efroni I., Savaldi-Goldstein S. (2021). “Auxin requirements for a meristematic state in roots depend on a dual brassinosteroid function”. Current Biology. DOI: 10.1016/j.cub.2021.07.075.
    • Avital A., Sadot-Muzika N., Persky Z., Bar G., Michaeli Y., Fridman Y., Karny A., Shklover J., Shainsky J., Savaldi-Goldstein S., Weissman H., Shoseyov O., Schroeder A. (2021). “Foliar Delivery of siRNA Particles for Treating Viral Infections in Agricultural Grapevines”. Advanced Functional Materials. DOI: 10.1002/adfm.202101003.
    • Sulkshane P., Ram J., Thakur A., Reis N., Kleifeld O., Glickman M.H. (2021). “Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia”. Redox Biology. DOI: 10.1016/j.redox.2021.102047.
    • Cohen Y., Margier M., Lesmes U., Reboul E., Livney Y.D. (2021). “Mechanisms of absorption of vitamin D3 delivered in protein nanoparticles in the absence and presence of fat”. Food & Function. DOI: 10.1039/d0fo02206c.
    • Oieni J., Lolli A., D’Atri D., Kops N., Yayon A., J.V.M. van Osch G., Machluf M. (2021). “Nano-ghosts: Novel biomimetic nano-vesicles for the delivery of antisense oligonucleotides”. Journal of Controlled Release. DOI: 10.1016/j.jconrel.2021.03.018
    • Kumarasamy M., Sosnik A. (2021). “Heterocellular spheroids of the neurovascular blood-brain barrier as a platform for personalized nanoneuromedicine”. iScience. DOI:10.1016/j.isci.2021.102183.
    • Stark M., Raz S., Assaraf Y.G. (2021). “Folylpoly-ɣ-glutamate synthetase association to the cytoskeleton: Implications to folate metabolon compartmentalization”. Journal of Proteomics. DOI: 10.1016/j.jprot.2021.104169.
    • Maroudas-Sacks Y., Garion L., Shani-Zerbib L., Livshits A., Braun E., Keren K. “Topological defects in the nematic order of actin fibers as organization centers of Hydra morphogenesis”. DOI: 10.1101/2020.03.02.972539.
    • Salinas N, Tayeb-Fligelman T., Sammito M., Bloch D., Jelinek R., Noy D., Uson I., Landau M. “The Amphibian Antimicrobial Peptide Uperin 3.5 is a Cross-α/Cross-β Chameleon Functional Amyloid”. bioRxiv. DOI:10.1101/2020.05.31.126045.
    • Engelberg, Y., Landau, M. (2020). “The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure”. Nature Communications. DOI:10.1038/s41467-020-17736-x.
    • Weiss L.E., Shalev Ezra Y., Goldberg S., Ferdman B., Adir O., Schroeder A., Alalouf O., Shechtman Y. (2020). “Three-dimensional localization microscopy in live flowing cells”. Nature Nanotechnology. DOI: 1038/s41565-020-0662-0.
    • Stark M., Silva, T.F.D., Levin G., Machuqueiro M., Assaraf Y.G., (2020). “The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal Membrane”. DOI: 10.3390/cells9051082.
    • Simaan H., Shalaby S., Hatoel M., Karinski O, Goldshmidt-Tran O., Horwitz B.A., (2020). Current Genetics. “The AP-1-like transcription factor ChAP1 balances tolerance and cell death in the response of the maize pathogen Cochliobolus heterostrophus to a plant phenolic”. Current Genet. DOI:10.1007/s00294-019-01012-7.
    • Tayeb-Fligelman E., Salinas N., Tabachnikov O., Landau M. (2020). “Staphylococcus aureus PSMα3 Cross-α Fibril Polymorphism and Determinants of Cytotoxicity”. Structure. DOI: 1016/j.str.2019.12.006.
    • Abumanhal-Masarweh H., da Silva D., Poley M., Zinger A., Goldman E., Krinsky N., Kleiner R., Shenbach G., Schroeder J.E., Shklover J., Shainsky-Roitman J., Schroeder A., (2019). “Tailoring the lipid composition of nanoparticles modulates their cellular uptake and affects the viability of triple negative breast cancer cells”, Journal of Controlled Release. DOI: 1016/j.jconrel.2019.06.025.
    • Massad-Ivanir N., Bhunia S., Raz N., Segal E., Jelinek R., (2018). “Synthesis and characterization of a nanostructured porous silicon/carbon dot-hybrid for orthogonal molecular detection”. NPG Asia Mater. DOI: 10.1038/am.2017.233.
    • Zinger A., Adir O., Alper M., Simon A., Poley M., Tzror C., Yaari Z., Krayem M., Kasten S., Nawy G., Herman A., Nir Y., Akrish S., Klein T., Shainsky-Roitman J., Hershkovitz D., Schroeder A., (2018). “Proteolytic Nanoparticles Replace a Surgical Blade by Controllably Remodeling the Oral Connective Tissue”. ACS Nano. DOI: 10.1021/acsnano.7b07983.
    • Engelberg S., Modrejewski J., Walter J.G., Livney Y.D., Assaraf Y.G., (2018). “Cancer cell-selective, clathrin-mediated endocytosis of aptamer decorated nanoparticles”. Oncotarget. DOI:10.18632/oncotarget.24772.
    • Singh A.P, Fridman Y., Holland N., Ackerman-Lavert M., Zananiri R., Jaillais Y., Henn A., Savaldi-Goldstein S., (2018). “Interdependent Nutrient Availability and Steroid Hormone Signals Facilitate Root Growth Plasticity”. Developmental Cell. DOI: 10.1016/j.devcel.2018.06.002.
    • Truman-Rosentsvit M., Berenbaum B, Spektor L., Cohen L.A., Belizowsky-Moshe S., Lifshitz L., Ma J., Lim W., Kesselman E., Abutbul-Ionita I., Danino D., Gutierrez L., Li H., Li K., Lou H., Regoni M., Poli M., Glaser F., Rouault T.A., Meyron-Holtz E.G., (2018). “Ferritin is secreted via 2 distinct nonclassical vesicular pathways”. Blood. DOI:10.1182/blood-2017-02-768580.
    • Krinsky N., Kaduri M., Zinger A., Shainsky‐Roitman J., Goldfeder M., Benhar I., Hershkovitz D., Schroeder A., (2018). “Synthetic Cells Synthesize Therapeutic Proteins inside Tumors”. Advanced Healthcare Materials. DOI: 10.1002/adhm.201701163.
    • Levin M., Stark M., Assaraf Y.G., (2018). “The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity”. Oncotarget. DOI:10.18632/oncotarget.24717.
    • Massad-Ivanir N, Bhunia S.K., Jelinek R., Segal E., (2018). “Porous Silicon Bragg Reflector/Carbon Dot Hybrids: Synthesis, Nanostructure, and Optical Properties”. Frontiers in Chemistry. DOI:10.3389/fchem.2018.00574.
    • Mishel S., Shneyer B., Korsensky L., Goldshmidt-Tran O., Haber T., Machluf M., Ron D., (2017). “Delivery of the gene encoding the tumor suppressor Sef into prostate tumors by therapeutic-ultrasound inhibits both tumor angiogenesis and growth”. Scientific Reports. DOI:10.1038/s41598-017-12408-1.
    • Goldshmid R., Seliktar D., (2017). “Hydrogel Modulus Affects Proliferation Rate and Pluripotency of Human Mesenchymal Stem Cells Grown in Three-Dimensional Culture”. ACS Biomaterials Science & Engineering. DOI:10.1021/acsbiomaterials.7b00266.
    • Abu-Zhayia E.R., Khoury-Haddad H., Guttmann-Raviv N., Serruya R., Jarrous N., Ayoub N., (2017). “A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks”. Scientific Reports. DOI:10.1038/s41598-017-01185-6.
    • Livshits A., Shani-Zerbib L., Maroudas-Sacks Y., Braun E., Keren K., (2017). “Structural Inheritance of the Actin Cytoskeletal Organization Determines the Body Axis in Regenerating Hydra”. Cell Reports. DOI:10.1016/j.celrep.2017.01.036.
    • Shneyer B.I., Ušaj M., Wiesel-Motiuk N., Regev R., Henn A., (2017). “ROS induced distribution of mitochondria to filopodia by Myo19 depends on a class specific tryptophan in the motor domain”. Scientific Reports. DOI:10.1038/s41598-017-11002-9.
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